Gastrointestinal (GI): NSAIDs that block COX-one action have correlations with GI complications as a result of inhibition from the synthesis of gastroprotective brokers including PGE2 and various prostaglandins. This inhibition brings about decreased mucin creation by gastric epithelial cells, less bicarbonate secretion, and fewer epithelial cell turnover, among other actions. https://giordanoo124npp8.wikifordummies.com/user